Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 23 April 1976:
Vol. 192. no. 4237, pp. 370 - 372
DOI: 10.1126/science.946556
Prev | Table of Contents | Next

Articles

Science, Vol 192, Issue 4237, 370-372
Copyright © 1976 by American Association for the Advancement of Science

articles

An inhibitor of macrophage chemotaxis produced by neoplasms

R Snyderman and MC Pike

The accumulation of macrophages at neoplastic sites may be an important event in immunologically mediated tumor killing. The implantation of syngeneic neoplasms in mice, however, was found to depress the animal's ability to localize macrophages at inflammatory sites. A low-molecular-weight (6,000 to 10,000) factor released by growing neoplasms that inhibits the accumulation of macrophages in vivo and chemotactic responsiveness in vitro was identified. The factor is active in the inhibition of macrophages and is ineffectual at retarding the migration of polymorphonuclear leukocytes. Neoplastic cells may thus abrogate immunosurveillance by releasing products that prevent potentially tumoricidal macrophages from accumulating at sites of developing malignancies.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Review : Polynucleotides as Interferon Inducers and Immune Modulators.
H. B. Levy (1986)
Journal of Bioactive and Compatible Polymers 1, 348-385
   PDF »
Defective Monocyte Chemotaxis in Patients With Head and Neck Cancer: Restoration After Treatment.
I. B. Tan, H. A. Drexhage, R. J. Scheper, B. M. von Blomberg-van der Flier, M. de Haan-Meulman, G. B. Snow, and A. J. M. Balm (1986)
Arch Otolaryngol Head Neck Surg 112, 541-544
   Abstract »    PDF »
Regulation of the macrophage content of neoplasms by chemoattractants.
B Bottazzi, N Polentarutti, R Acero, A Balsari, D Boraschi, P Ghezzi, M Salmona, and A Mantovani (1983)
Science 220, 210-212
   Abstract »    PDF »
Tumor surveillance: how tumors may resist macrophage-mediated host defense.
J Rhodes, M Bishop, and J Benfield (1979)
Science 203, 179-182
   Abstract »    PDF »
Monocytes and Macrophages: Functions and Diseases.
M. J. CLINE, R. I. LEHRER, M. C. TERRITO, and D. W. GOLDE (1978)
Ann Intern Med 88, 78-88
   Abstract »    PDF »
Immunotherapy of cancer with antibody.
H. Shin, G. Pasternack, J. Economou, R. Johnson, and M. Hayden (1976)
Science 194, 327-329
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)