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Science 23 April 1976:
Vol. 192. no. 4237, pp. 370 - 372
DOI: 10.1126/science.946556
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Articles

Science, Vol 192, Issue 4237, 370-372
Copyright © 1976 by American Association for the Advancement of Science

articles

An inhibitor of macrophage chemotaxis produced by neoplasms

R Snyderman and MC Pike

The accumulation of macrophages at neoplastic sites may be an important event in immunologically mediated tumor killing. The implantation of syngeneic neoplasms in mice, however, was found to depress the animal's ability to localize macrophages at inflammatory sites. A low-molecular-weight (6,000 to 10,000) factor released by growing neoplasms that inhibits the accumulation of macrophages in vivo and chemotactic responsiveness in vitro was identified. The factor is active in the inhibition of macrophages and is ineffectual at retarding the migration of polymorphonuclear leukocytes. Neoplastic cells may thus abrogate immunosurveillance by releasing products that prevent potentially tumoricidal macrophages from accumulating at sites of developing malignancies.


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