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Science 9 April 1976:
Vol. 192. no. 4235, pp. 155 - 158
DOI: 10.1126/science.56781
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Articles
Science, Vol 192, Issue 4235, 155-158
Copyright © 1976 by American Association for the Advancement of Science
Induction of mitosis in mature neurons in central nervous system by sustained depolarization
CD Cone Jr
and
CM Cone
DNA synthesis and mitosis have been induced in vitro in fully differentiated neurons from the central nervous system by depolarization with a variety of agents that produce a sustained rise in the intracellular sodium ion concentration and a decrease in the potassium ion concentration. Depolarization was followed in less than 1 hour by an increase in RNA synthesis and in 3 hours by initiation of DNA synthesis. Apparently normal nuclear mitosis ensued, but cytokinesis was not completed in most cells; this resulted in the formation of binucleate neurons. The daughter nuclei each contained the same amount of DNA as the diploid preinduction parental neurons; this implies that true mitogenic replication was induced.
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