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Science 2 April 1976:
Vol. 192. no. 4234, pp. 62 - 64
DOI: 10.1126/science.176726
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Articles
Science, Vol 192, Issue 4234, 62-64
Copyright © 1976 by American Association for the Advancement of Science
Theiler's virus-induced demyelination: prevention by immunosuppression
HL Lipton
and
MC Dal Canto
The effect of immunosuppression with cyclophosphamide and rabbit antiserum to mouse thymocytes on demyelination induced by Theiler's virus in SJL/J mice was ascertained from Epon-embedded sections (1 micrometer) of the central nervous system. Immunosuppression not only eliminated mononuclear cell infiltrates in the spinal cord white matter, but it also prevented the occurrence of demyelination. These results suggest that demyelination in this infection is immune-mediated.
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