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Science 2 April 1976:
Vol. 192. no. 4234, pp. 53 - 54
DOI: 10.1126/science.1257755
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Articles

Science, Vol 192, Issue 4234, 53-54
Copyright © 1976 by American Association for the Advancement of Science

articles

Nonenzymic joining of oligoadenylates on a polyuridylic acid template

DA Usher and AH McHale

3',5'-Linked hexa-adenylic acid with a 2',3'-cyclic phosphate terminus [(A5A less than p] couples on a polyuridylic acid template in the presence of ethylenediamine to form the dodecamer (24 percent) and octadecamer (5 percent). The bond produced is largely that of the 2',5' isomer.


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