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Science 26 March 1976:
Vol. 191. no. 4233, pp. 1275 - 1276
DOI: 10.1126/science.56780
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Articles

Science, Vol 191, Issue 4233, 1275-1276
Copyright © 1976 by American Association for the Advancement of Science

articles

Cobra venom factor: evidence for its being altered cobra C3 (the third component of complement)

CA Alper and D Balavitch

Evidence is presented that cobra venom factor, the anticomplementary protein in Naja naja venom, is modified cobra C3 (the third component of complement). Antiserum to the cobra venom factor cross reacts with human C3. A protein in cobra serum reacts strongly with antiserum to the venom factor and the former protein, like human C3, is converted by incubation of cobra serum with endotoxin, hydrazine, or simple storage at 37 degrees C. Incubation of cobra venom factor with cobra serum destroys the C3 cleaving activity of the venom factor in human serum, whereas human C3b inactivator is ineffective. Thus, the cobra venom factor appears to be a form of C3 (perhaps C3b); its potent action in human serum probably derives from its lack of sensitivity to human C3b inactivator.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Role of Complement in Defense of the Middle Ear Revealed by Restoring the Virulence of Nontypeable Haemophilus influenzae siaB Mutants.
M. A. Figueira, S. Ram, R. Goldstein, D. W. Hood, E. R. Moxon, and S. I. Pelton (2007)
Infect. Immun. 75, 325-333
   Abstract »    Full Text »    PDF »
Complement Inactivation by Recombinant Human C3 Derivatives.
J. Kolln, E. Spillner, J. Andra, K. Klensang, and R. Bredehorst (2004)
J. Immunol. 173, 5540-5545
   Abstract »    Full Text »    PDF »
Structure and Function of Recombinant Cobra Venom Factor.
M. A. Kock, B. E. Hew, H. Bammert, D. C. Fritzinger, and C.-W. Vogel (2004)
J. Biol. Chem. 279, 30836-30843
   Abstract »    Full Text »    PDF »
C3a and C3b Activation Products of the Third Component of Complement (C3) Are Critical for Normal Liver Recovery after Toxic Injury.
M. M. Markiewski, D. Mastellos, R. Tudoran, R. A. DeAngelis, C. W. Strey, S. Franchini, R. A. Wetsel, A. Erdei, and J. D. Lambris (2004)
J. Immunol. 173, 747-754
   Abstract »    Full Text »    PDF »
Inhibition of a Membrane Complement Regulatory Protein by a Monoclonal Antibody Induces Acute Lethal Shock in Rats Primed with Lipopolysaccharide.
M. Mizuno, K. Nishikawa, N. Okada, S. Matsuo, K. Ito, and H. Okada (1999)
J. Immunol. 162, 5477-5482
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)