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Science 26 March 1976:
Vol. 191. no. 4233, pp. 1264 - 1266
DOI: 10.1126/science.1257745
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Articles

Science, Vol 191, Issue 4233, 1264-1266
Copyright © 1976 by American Association for the Advancement of Science

articles

Elimination of the sarcoma genome from murine sarcoma virus transformed cat cells

AS Frankel, DK Haapala, RL Neubauer, and PJ Fischinger

Cat cells transformed by Moloney murine sarcoma virus contain virus-specific sequences in their RNA and DNA. Cloned, spontaneous revertant cell lines derived from clones of these cells had no evidence of the sarcoma genome in the cell RNA or DNA as judged by RNA-complementary DNA or DNA-complementary DNA hybridizations. ?This is apparently the first report of loss of a transforming genome in a revertant cell line.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Expression of the src-gene Product, pp60src, in Transformed and Reverted Mammalian Cells Infected with Avian Sarcoma Virus.
A. F. Lau, R. A. Krzyzek, J. S. Brugge, M. S. Collett, R. L. Erikson, and A. J. Faras (1980)
Cold Spring Harb Symp Quant Biol 44, 1057-1064
   Abstract »    PDF »
Factors Affecting Phenotypic Reversion of Rat Cells Transformed by Avian Sarcoma Virus.
J. A. Wyke, J. A. Beamand, and H. E. Varmus (1980)
Cold Spring Harb Symp Quant Biol 44, 1065-1075
   Abstract »    PDF »


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