Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 26 March 1976:
Vol. 191. no. 4233, pp. 1262 - 1264
DOI: 10.1126/science.943846
Prev | Table of Contents | Next

Articles

Science, Vol 191, Issue 4233, 1262-1264
Copyright © 1976 by American Association for the Advancement of Science

articles

Hemoglobin synthesis in somatic cell hybrids: independent segregation of the human alpha- and beta-globin genes

A Deisseroth, R Velez, and AW Nienhuis

Hybrid somatic cells containing a partial complement of human chromosomes were used to demonstrate that the human alpha- and beta-globin genes are located on different chromosomes. Two cell lines consisting of a cross of mouse with human fibroblasts contained the human alpha- and not the beta-globin gene, while a cross of human marrow cells with mouse erythroleukemia cells expressed the human beta- but not the alpha-globin gene.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Genomic evidence for independent origins of {beta}-like globin genes in monotremes and therian mammals.
J. C. Opazo, F. G. Hoffmann, and J. F. Storz (2008)
PNAS 105, 1590-1595
   Abstract »    Full Text »    PDF »
Stability of the individual globin genes during erythroid differentiation.
E Benz Jr, P Turner, J Barker, and A Nienhuis (1977)
Science 196, 1213-1214
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)