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Science 19 March 1976:
Vol. 191. no. 4232, pp. 1185 - 1187
DOI: 10.1126/science.3851
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Articles

Science, Vol 191, Issue 4232, 1185-1187
Copyright © 1976 by American Association for the Advancement of Science

articles

Sperm diaphorase: genetic polymorphism of a sperm-specific enzyme in man

K Caldwell, ET Blake, and GF Sensabaugh

Human sperm contains en enzyme with diaphorase activity that appears to be unique to sperm. Electrophoretic analysis of the diaphorase activity in sperm of different individuals reveals three phenotypic patterns. This polymorphism can be explained in terms of two alleles segregating at an autosomal locus; the allele frequencies have been determined to be 0.71 and 0.29. This appears to be the first reported example of a sperm-specific genetic polymorphism in man; its existence raises a number of genetic and biochemical questions.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Morphometric assessment of mature and diminished-maturity human spermatozoa: sperm regions that reflect differences in maturity.
A. Gergely, E. Kovanci, L. Senturk, E. Cosmi, L. Vigue, and G. Huszar (1999)
Hum. Reprod. 14, 2007-2014
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