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Science 27 February 1976:
Vol. 191. no. 4229, pp. 862 - 865
DOI: 10.1126/science.175442
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Articles

Science, Vol 191, Issue 4229, 862-865
Copyright © 1976 by American Association for the Advancement of Science

articles

Estrogen receptor in the mammalian liver

AJ Eisenfeld, R Aten, M Weinberger, G Haselbacher, K Halpern, and L Krakoff

The cytosol from livers of adult female mammals contains [3H]estradiol-binding proteins that can translocate to the nucleus and attach to chromatin. In comparison to the prepubescent rat, adults have higher estrogen binding in the liver and greater increases in plasma renin substrate after administration of estrogen. The protein in the liver which binds estrogen may be an estrogen receptor involved in modulating hepatic synthesis of selective plasma proteins.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Nuclear Hormone Receptors as Regulators of the Renin-Angiotensin-Aldosterone System.
I. Kuipers, P. van der Harst, G. Navis, L. van Genne, F. Morello, W. H. van Gilst, D. J. van Veldhuisen, and R. A. de Boer (2008)
Hypertension 51, 1442-1448
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Hepatitis B virus X protein and the estrogen receptor variant lacking exon 5 inhibit estrogen receptor signaling in hepatoma cells.
J. Han, L. Ding, B. Yuan, X. Yang, X. Wang, J. Li, Q. Lu, C. Huang, and Q. Ye (2006)
Nucleic Acids Res. 34, 3095-3106
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Differentially Expressed Messenger RNA Isoforms of the Human Estrogen Receptor-{alpha} Gene Are Generated by Alternative Splicing and Promoter Usage.
G. Flouriot, C. Griffin, M. Kenealy, V. Sonntag-Buck, and F. Gannon (1998)
Mol. Endocrinol. 12, 1939-1954
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Localized Aberrant Expression of Cytochrome P450 Aromatase in Primary and Metastatic Malignant Tumors of Human Liver.
N. Harada, H. Ota, N. Yoshimura, T. Katsuyama, and Y. Takagi (1998)
J. Clin. Endocrinol. Metab. 83, 697-702
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Importance of Estrogen Receptors in Hepatic LDL Receptor Regulation.
P. Parini, B. Angelin, and M. Rudling (1997)
Arterioscler Thromb Vasc Biol 17, 1800-1805
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Focal Nodular Hyperplasia of the Liver Associated With High-Dosage Estrogens.
K. Aldinger, Y. Ben-Menachem, and G. Whalen (1977)
Arch Intern Med 137, 357-359
   Abstract »    PDF »
Colonic Neoplasms: Tissue Estrogen Receptor and Carcinoembryonic Antigen.
J. E. McClendon, D. Appleby, D. B. Claudon, W. L. Donegan, and J. J. DeCosse (1977)
Arch Surg 112, 240-241
   Abstract »    PDF »
Systemic Contraceptives and Liver Tumors.
J. Q. STAUFFER and R. B. HILL (1976)
Ann Intern Med 85, 122-123
   Abstract »    PDF »


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