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Science 27 February 1976:
Vol. 191. no. 4229, pp. 858 - 859
DOI: 10.1126/science.1251198
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Articles

Science, Vol 191, Issue 4229, 858-859
Copyright © 1976 by American Association for the Advancement of Science

articles

Demonstration of kinetoplast DNA in dyskinetoplastic strains of Trypanosoma equiperdum

SL Hajduk

4,6 Diamidino-2-phenylindole (DAPI) forma a highly fluorescent complex with DNA which allows detection of mitochondrial DNA (K-DNA) in normal and dyskinetoplastic strains of Trypanosoma equiperdum. The K-DNA DAPI complexes in the dyskinetoplastic cells, cells lacking detactable K-DNA by other cytochemical methods, are not restricted to a single region of the organism as in the normal strain, but are seen as a row of particles. These observations support the hypothesis that the K-DNA is retained in dyskinetoplastic cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Macrophage-Specific Lipid-Based Nanoparticles Improve Cardiac Magnetic Resonance Detection and Characterization of Human Atherosclerosis..
M. J. Lipinski, J. C. Frias, V. Amirbekian, K. C. Briley-Saebo, V. Mani, D. Samber, A. Abbate, J. G. S. Aguinaldo, D. Massey, V. Fuster, et al. (2009)
J. Am. Coll. Cardiol. Img. 2, 637-647
   Abstract »    Full Text »    PDF »
Mitochondrial Development during Life Cycle Differentiation of African Trypanosomes: Evidence for a Kinetoplast-dependent Differentiation Control Point.
M. W. Timms, F. J. van Deursen, E. F. Hendriks, and K. R. Matthews (2002)
Mol. Biol. Cell 13, 3747-3759
   Abstract »    Full Text »    PDF »


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