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Science 13 February 1976:
Vol. 191. no. 4227, pp. 578 - 579
DOI: 10.1126/science.943127
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Articles

Science, Vol 191, Issue 4227, 578-579
Copyright © 1976 by American Association for the Advancement of Science

articles

Environmental stimulation reduces learning deficits in experimental cretinism

JW Davenport, LM Gonzalez, JC Carey, SB Bishop, and WW Hagquist

Behavioral deficits in adult rats exposed perinatally to thiouracil were substantially reduced or elimated by a 5-week period of "superenriched" postweaning rearing conditions before testing. This treatment resulted in remediation of hypothyroid rats' deficits in maze learning, maze retention, and resistance to extinction of bar-pressing; the facilitative effect persisted for more than 4 months. These behavioral results were consistent with neurohistological findings from studies of early thyroid deficiency and postweaning environmental stimulation in rats.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)