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Science 13 February 1976:
Vol. 191. no. 4227, pp. 561 - 562
DOI: 10.1126/science.1251187
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Articles

Science, Vol 191, Issue 4227, 561-562
Copyright © 1976 by American Association for the Advancement of Science

articles

Brain acetylcholine: control by dietary choline

EL Cohen and RJ Wurtman

Acetylcholine concentrations in whole rat brain or in various brain regions and free choline concentrations in blood serum and brain vary with dietary choline consumption. The increases in brain acetylcholine after treatment with physositigmine (an inhibitor of actylcholinesterase) or after consumption of a diet high in choline are additive, suggesting that choline acts by increasing acetylcholine synthesis.


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