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Science 6 February 1976:
Vol. 191. no. 4226, pp. 483 - 484
DOI: 10.1126/science.1246633
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Articles

Science, Vol 191, Issue 4226, 483-484
Copyright © 1976 by American Association for the Advancement of Science

articles

Adrenaline-forming enzyme in brainstem: elevation in genetic and experimental hypertension

JM Saavedra, H Grobecker, and J Axelrod

The adrenaline-forming enzyme (phenylethanolamine N-methyltransferase) was elevated in the A1 and A2 regions of the brainstem of 4-week-old spontaneously (genetic) hypertensive rats and in the A1 region of adult experimentally (deoxycorticosterone acetate and sodium chloride) hypertensive rats. The administration of a phenylethanolamine N-methyltransferase inhibitor to experimentally hypertensive animals caused a reduction of the elevated blood pressure to normal values. These results implicate adrenaline-containing neurons in the brainstem in the development of hypertension.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Variation in the Region of the Angiotensin-Converting Enzyme Gene Influences Interindividual Differences in Blood Pressure Levels in Young White Males.
M. Fornage, C. I. Amos, S. Kardia, C. F. Sing, S. T. Turner, and E. Boerwinkle (1998)
Circulation 97, 1773-1779
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Investigation of the Phenylethanolamine N-Methyltransferase Gene as a Candidate Gene for Hypertension.
G. Koike, H. J. Jacob, J. E. Krieger, C. Szpirer, M. R. Hoehe, M. Horiuchi, and V. J. Dzau (1995)
Hypertension 26, 595-601
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3-Methoxy-4-hydroxyphenylglycol in cerebrospinal fluid and vanillylmandelic acid in urine of humans with hypertension.
R. Saran, R. Sahuja, N. Gupta, M Hasan, K. Bhargava, K Shanker, and K Kishor (1978)
Science 200, 317-318
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