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Science 23 January 1976:
Vol. 191. no. 4224, pp. 305 - 308
DOI: 10.1126/science.942800
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Articles

Science, Vol 191, Issue 4224, 305-308
Copyright © 1976 by American Association for the Advancement of Science

articles

Selective brain dopamine depletion in developing rats: an experimental model of minimal brain dysfunction

BA Shaywitz, RD Yager, and JH Klopper

Administration of 6-hydroxydopamine to neonatal rats produces a rapid and profound depletion of brain dopamine. Total activity of treated animals is significantly greater than that of controls between 12 and 22 days of age, but then declines, an activity pattern similar to that seen in affected children. This suggests a functional deficiency of brain dopamine in the pathogenesis of minimal brain dysfunction.


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Environmental influences on body weight and behavior in developing rats after neonatal 6-hydroxydopamine.
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The Hyperactive Child: Should We Be Paying More Attention?.
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Arch Pediatr Adolesc Med 133, 413-418
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Methylphenidate in 6-Hydroxydopamine-Treated Developing Rat Pups: Effects on Activity and Maze Performance.
B. A. Shaywitz, J. H. Klopper, and J. W. Gordon (1978)
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A Reply.
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Paradoxical effects of amphetamine on preweanling and postweanling rats.
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Minimal brain dysfunction:dopamine depletion?.
(1976)
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Minimal Brain Dysfunction: Dopamine Depletion?.
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Science 194, 452-453
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Minimal Brain Dysfunction.
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JAMA 235, 1967
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