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Science 23 January 1976:
Vol. 191. no. 4224, pp. 301 - 302
DOI: 10.1126/science.1108199
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Articles

Science, Vol 191, Issue 4224, 301-302
Copyright © 1976 by American Association for the Advancement of Science

articles

Melatonin inhibition of the neonatal pituitary response to luteinizing hormone-releasing factor

JE Martin and DC Klein

Neonatal rat anterior pituitary glands treated in organ culture with 1 nanomolar luteinzing hormone-releasing factor (LRF) showed a tenfold increase in medium luteinizing hormone (LH) concentrations over control values. Simultaneous treatment of the glands with 1 nanomolar melatonin significantly reduced the stimulatory effect of LRF on release of LH. This finding indicates that melatonin can act directly on the neonatal pituitary to inhibit the LH response to LRF.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Gonadotrophin-releasing hormone drives melatonin receptor down-regulation in the developing pituitary gland.
J. D. Johnston, S. Messager, F. J. P. Ebling, L. M. Williams, P. Barrett, and D. G. Hazlerigg (2003)
PNAS 100, 2831-2835
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Direct Action of Melatonin in Human Granulosa-Luteal Cells.
M. M. M. Woo, C.-J. Tai, S. K. Kang, P. S. Nathwani, S. F. Pang, and P. C. K. Leung (2001)
J. Clin. Endocrinol. Metab. 86, 4789-4797
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Cellular Mechanisms of Melatonin Action.
J. VANECEK (1998)
Physiol Rev 78, 687-721
   Abstract »    Full Text »    PDF »
Melatonin: a coordinating signal for mammalian reproduction?.
L Tamarkin, C. Baird, and O. Almeida (1985)
Science 227, 714-720
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Science. ISSN 0036-8075 (print), 1095-9203 (online)