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Science 16 January 1976:
Vol. 191. no. 4223, pp. 195 - 197
DOI: 10.1126/science.1108196
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Articles

Science, Vol 191, Issue 4223, 195-197
Copyright © 1976 by American Association for the Advancement of Science

articles

Blockage of ovulation in rats by inhibitory analogs of luteinizing hormones-releasing hormone

A De la Cruz, DH Coy, JA Vilchez-Martinez, A Arimura, and AV Schelly

An antagonist of luteinizing hormone-releasing hormone (LH-RH). [D-Phe2-Phe3-D-Phe6]-LH-RH (Phe, phenylalanine), suppressed luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release in male rats in response to LH-RH for at least 4 hours. Three subcutaneous injection of 1 milligram of this antagonist into rats during proestrus completely suppressed ovulation, while a single injection of 1.5 milligrams per rat inhibited 95.3 percent of the preovulatory surge of LH, 84.2 percent of the FSH surge, and suppressed ovulation by 86.4 percent.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Suppression of ovulation in the rat by an orally active antagonist of luteinizing hormone-releasing hormone.
M. Nekola, A Horvath, L. Ge, D. Coy, and A. Schally (1982)
Science 218, 160-162
   Abstract »    PDF »
Antireproductive effects of a potent gonadotropin-releasing hormone antagonist in the male rat.
C Rivier, J Rivier, and W Vale (1980)
Science 210, 93-95
   Abstract »    PDF »
Aspects of hypothalamic regulation of the pituitary gland.
A. Schally (1978)
Science 202, 18-28
   PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)