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Science 16 January 1976:
Vol. 191. no. 4223, pp. 188 - 191
DOI: 10.1126/science.1246607
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Articles

Science, Vol 191, Issue 4223, 188-191
Copyright © 1976 by American Association for the Advancement of Science

articles

Cytoplasmic microtubule organizing centers isolated from Polytomella agilis

ME Stearns, JA Connolly, and DL Brown

Basal body rootlets in Polytomella function as organizing centers for cytoplasmic microtbules in vivo. A method is described to isolate intact basal body-rootlet complexes. The integrity of the isolated complexes is confirmed by electron microscopy, and the rootlets are shown to be competent as initiation sites for the in vitro polymerization of brain microtubule protein.


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The Genetics of Alzheimer's Disease: Associations With Hematologic Malignancy and Down's Syndrome.
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