Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 16 January 1976:
Vol. 191. no. 4223, pp. 185 - 187
DOI: 10.1126/science.942798
Prev | Table of Contents | Next

Articles

Science, Vol 191, Issue 4223, 185-187
Copyright © 1976 by American Association for the Advancement of Science

articles

Metaphase chromosome anomaly: association with drug resistance and cell-specific products

JL Biedler and BA Spengler

Large, homogeneously staining chromosome regions which lack the longitudinal differentiation ordinarily revealed by cytogenetic "banding" methods have been found in antifolate-resistant Chinese hamster cells and also in human neuroblastoma cells established in vitro. The drug-resistant cells are characterized by excessive production of the target enzyme, dihydrofolate reducatase, while the human neuroblastoma cells have phenotypes of normal neuronal cells. The homogeneously staining region appears to represent a novel metaphase chromosome anaomaly which may have functional significance in cells with specialized properties.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Genome Health Clinic and Genome Health Nutrigenomics concepts: diagnosis and nutritional treatment of genome and epigenome damage on an individual basis.
M. Fenech (2005)
Mutagenesis 20, 255-269
   Abstract »    Full Text »    PDF »
The Effect of Folic Acid Deficiency and MTHFR C677T Polymorphism on Chromosome Damage in Human Lymphocytes in Vitro.
J. W. Crott, S. T. Mashiyama, B. N. Ames, and M. Fenech (2001)
Cancer Epidemiol. Biomarkers Prev. 10, 1089-1096
   Abstract »    Full Text »    PDF »
Distinct patterns of alteration of myc genes associated with integration of human papillomavirus type 16 or type 45 DNA in two genital tumours.
X. Sastre-Garau, M. Favre, J. Couturier, and G. Orth (2000)
J. Gen. Virol. 81, 1983-1993
   Abstract »    Full Text »
Internalization and Recycling of delta -Opioid Receptor Are Dependent on a Phosphorylation-Dephosphorylation Mechanism.
A. Hasbi, S. Allouche, F. Sichel, L. Stanasila, D. Massotte, G. Landemore, J. Polastron, and P. Jauzac (2000)
J. Pharmacol. Exp. Ther. 293, 237-247
   Abstract »    Full Text »
Deletion of a Recombined Ig Heavy Chain Transgene in B-Lineage Cells of Transgenic Mice.
A. Heinzelmann, S. Kumar, S. Noggle, I. Goedegebuur, K. M. Sauer, S. Rath, and J. M. Durdik (1998)
J. Immunol. 161, 666-673
   Abstract »    Full Text »    PDF »
Excess Fruit Juice Consumption by Preschool-aged Children Is Associated With Short Stature and Obesity.
B. A. Dennison, H. L. Rockwell, and S. L. Baker (1997)
Pediatrics 99, 15-22
   Abstract »    Full Text »    PDF »
Chromatin organization in the homogeneously staining regions of a methotrexate-resistant mouse cell line: interspersion of inactive and active chromatin domains distinguished by acetylation of histone H4.
L Nicol and P Jeppesen (1996)
J. Cell Sci. 109, 2221-2228
   Abstract »    PDF »
Loss of Chromosomal Integrity in Neoplasia.
T.D. Tlsty, P. Jonczyk, A White, M. Sage, I. Hall, D. Schaefer, A. Briot, E. Livanos, H. Roelofs, B. Poulose, et al. (1993)
Cold Spring Harb Symp Quant Biol 58, 645-654
   Abstract »    PDF »
Chromosomal and Extrachromosomal Localization of Amplified Dihydrofolate Reductase Genes in Cultured Mammalian Cells.
R. T. Schimke, P. C. Brown, R. J. Kaufman, M. McGrogan, and D. L. Slate (1981)
Cold Spring Harb Symp Quant Biol 45, 785-797
   Abstract »    PDF »
Gene amplification and drug resistance in cultured murine cells.
R. Schimke, R. Kaufman, F. Alt, and R. Kellems (1978)
Science 202, 1051-1055
   Abstract »    PDF »
Amplification of Dihydrofolate Reductase Genes in Methotrexate-resistant Cultured Mouse Cells.
R. T. Schimke, F. W. Alt, R. E. Kellems, R. J. Kaufman, and J. R. Bertino (1978)
Cold Spring Harb Symp Quant Biol 42, 649-657
   Abstract »    PDF »
Double minute chromosomes and the homogeneously staining regions in chromosomes of a human neuroblastoma cell line.
G Balaban-Malenbaum and F Gilbert (1977)
Science 198, 739-741
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)