Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 9 January 1976:
Vol. 191. no. 4222, pp. 90 - 92
DOI: 10.1126/science.1246599
Prev | Table of Contents | Next

Articles

Science, Vol 191, Issue 4222, 90-92
Copyright © 1976 by American Association for the Advancement of Science

articles

Extracellular potassium accumulation and inward-going potassium rectification in voltage clamped ventricular muscle

L Cleemann and M Morad

Measurements of afterpotential, action potential duration, and output of a potassium-sensitive microelectrode indicate that the application of long clamp pulses (1 to 8 seconds) to frog ventricular muscle is accompanied by a change in the extracellular potassium concentration. The plot of the magnitude of the potassium accumulation against the clamped membrane potential yields an N-shaped relation similar to the "steady state" current-voltage relation. The accumulation studies confirm a strong inward-going (anomalous) potassium rectification.




To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)