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Science 9 January 1976:
Vol. 191. no. 4222, pp. 88 - 90
DOI: 10.1126/science.1108194
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Articles

Science, Vol 191, Issue 4222, 88-90
Copyright © 1976 by American Association for the Advancement of Science

articles

Microtubule assembly and the intracellular transport of secretory granules in pancreatic islets

DG Pipeleers, MA Pipeleers-Marichal, and DM Kipnis

Polymerized and depolymerized tubulin were measured in pancreatic islets under various physiological and pharmacological conditions. Variations in insulin release from islets of fed or fasted rats were accompanied by concomitant changes in tubulin polymerization. Glucose induced the formation of microtubules in vitro independent of extracellular calcium. Total and polymerized tubulin content were decreased by fasting and restored by glucose feeding.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Threonine phosphorylations induced by RX-871024 and insulin secretagogues in beta TC6-F7 cells.
J. An, G. Zhao, L. M. Churgay, J. J. Osborne, J. E. Hale, G. W. Becker, G. Gold, L. E. Stramm, and Y. Shi (1999)
Am J Physiol Endocrinol Metab 277, E862-E869
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Calcium-stimulated Phosphorylation of MAP-2 in Pancreatic beta TC3-cells Is Mediated by Ca2+/Calmodulin-dependent Kinase II.
K. A. Krueger, H. Bhatt, M. Landt, and R. A. Easom (1997)
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Intracellular accumulation of T-cell receptor complex molecules in a human T-cell line.
D. Tse, M Al-Haideri, B Pernis, C. Cantor, and C. Wang (1986)
Science 234, 748-751
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The Genetics of Alzheimer's Disease: Associations With Hematologic Malignancy and Down's Syndrome.
L. L. Heston and A. R. Mastri (1977)
Arch Gen Psychiatry 34, 976-981
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