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Science 19 December 1975:
Vol. 190. no. 4220, pp. 1230 - 1231
DOI: 10.1126/science.128123
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Articles

Science, Vol 190, Issue 4220, 1230-1231
Copyright © 1975 by American Association for the Advancement of Science

articles

Inferior olive: its role in motor learing

R Llinas, K Walton, DE Hillman, and C Sotelo

Specific chemical lesion of the rat inferior olive by intraperitoneal administration of 3-acetylpyridine prevents recuperation from motor abnormalities generated by unilateral labyrinthine lesion. Moreover, in animals that have recuperated from the balyrinthine lesion, 3-acetylpyridine produces a reversal of the symptoms within 2 hours of administration. These results indicate that the integrity of the olivo-cerebellar system is necessary for the acquisition and retention of this form of motor learning, but that the cerebellum itself is not the seat of such learning.


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