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Science 19 December 1975:
Vol. 190. no. 4220, pp. 1211 - 1213
DOI: 10.1126/science.1081736
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Articles

Science, Vol 190, Issue 4220, 1211-1213
Copyright © 1975 by American Association for the Advancement of Science

articles

Differentiation of T cells in nude mice

MP Schedi, G Goldstein, and EA Boyce

Cells bearing the T-cell differentiation alloantigens TL and Thy-1 were enumerated in preparations of spleen and lymph node cells of nu/nu mice. Healthy nu/nu mice had few or no demonstrable TL+ or Thy-1+ cells whereas mice with viral hepatitis, including some born of nu/nu X nu/nu matings, had many. Healthy nu/nu mice were treated daily with the thymic hormone thymopoietin or with ubiquitin, polypeptides that induce the differentiation of TL+Thy-1" cells from TL-Thy-1- precursors in vitro. After 14 days, 20 to 40 percent of their spleen cells were of the TL+Thy-1+ phenotype typical of thymocytes and 10 to 25 percent of their lymph node cells were TL-Thy-1+, typical of later T-cell differentiation. Similar frequencies of such cells were found in untreated nu/nu mice suffering from severe viral hepatitis. These data conform to the current view that prothymocytes are preprogrammed cells whose maturation to thymocytes, normally induced in the thymus by thymopoietin, can be triggered by other agents under abnormal circumstances. Tests of T-cell function were not included in this study.


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Arginine Enhances T-Cell Responses in Athymic Nude Mice.
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A synthetic pentapeptide with biological activity characteristic of the thymic hormone thymopoietin.
G Goldstein, M. Scheid, E. Boyse, D. Schlesinger, and J Van Wauwe (1979)
Science 204, 1309-1310
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Specialized DNA Polymerases in Lymphoid Cells.
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