Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 19 December 1975:
Vol. 190. no. 4220, pp. 1206 - 1209
DOI: 10.1126/science.1198107
Prev | Table of Contents | Next

Articles

Science, Vol 190, Issue 4220, 1206-1209
Copyright © 1975 by American Association for the Advancement of Science

articles

Minor salivary glands as a major source of secretory immunoglobin A in the human oral cavity

JM Crawford, MA Taubman, and DJ Smith

Secretory immunoglobulin A is the predominant immunoglobulin in labial minor salivary gland secretions. Its mean concentration is four times higher in these secretions than in parotid gland secretion. The minor salivary glands can produce 30 to 35 percent of the immunoglobulin A that enters the oral cavity. This, together with the potential accessibility of these glands to antigenic stimulation, suggest that they may be an important source of the immune factors that are involved in the regulation of the microorganisms in the oral environment.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Proteome of Human Minor Salivary Gland Secretion.
W.L. Siqueira, E. Salih, D.L. Wan, E.J. Helmerhorst, and F.G. Oppenheim (2008)
Journal of Dental Research 87, 445-450
   Abstract »    Full Text »    PDF »
Oral Mucosal Immunity and HIV/SIV Infection.
F.X. Lu and R.S. Jacobson (2007)
Journal of Dental Research 86, 216-226
   Abstract »    Full Text »    PDF »
DENTAL CARIES VACCINES: PROSPECTS AND CONCERNS.
D.J. Smith (2002)
Critical Reviews in Oral Biology & Medicine 13, 335-349
   Abstract »    Full Text »    PDF »
The Flow Rate of Unstimulated Human Labial Gland Saliva.
D.B. Ferguson (1996)
Journal of Dental Research 75, 980-985
   Abstract »    PDF »
Change of Salivary IgA Secretion and Caries Development in Irradiated Rats.
T. Takei, W. Aono, S. Nagashima, T. Yoshida, T. Hashida, S. Sobue, and T. Ooshima (1994)
Journal of Dental Research 73, 1503-1508
   Abstract »    PDF »
Sialochemistry: A Diagnostic Tool?.
A. Aguirre, L.A. Testa-Weintraub, J.A. Banderas, G.G. Haraszthy, M.S. Reddy, and M.J. Levine (1993)
Critical Reviews in Oral Biology & Medicine 4, 343-350
   Abstract »    Full Text »    PDF »
Effect of Age on Immunoglobulin Content and Volume of Human Labial Gland Saliva.
D.J. Smith, K. Joshipura, R. Kent, and M.A. Taubman (1992)
Journal of Dental Research 71, 1891-1894
   Abstract »    PDF »
Immunoglobulin Isotypes in Human Minor Gland Saliva.
D.J. Smith, M.A. Taubman, and P. Ali-Salaam (1991)
Journal of Dental Research 70, 167-170
   Abstract »    PDF »
A Method for Measuring the Flow of Saliva from the Minor Salivary Glands.
R.J. Shern, P.C. Fox, J.L. Cain, and S.-H. Li (1990)
Journal of Dental Research 69, 1146-1149
   Abstract »    PDF »
Age-related Salivary Flow Rate Changes in Controls and Patients with Oral Lichen Planus.
B.K. Gandara, K.T. Izutsu, E.L. Truelove, W.Y. Ensign, and E.E. Sommers (1985)
Journal of Dental Research 64, 1149-1151
   Abstract »    PDF »
Basic Biological Sciences Relationship between Concentration of Human Salivary Statherin and Inhibition of Calcium Phosphate Precipitation in Stimulated Human Parotid Saliva.
D.I. Hay, D.J. Smith, S.K. Schluckebier, and E.C. Moreno (1984)
Journal of Dental Research 63, 857-863
   Abstract »    PDF »
Naturally-occurring IgA Antibodies to Glycerol-teichoic Acid in Human Saliva. Correlation with Caries Activity.
R. W. Bolton (1981)
Journal of Dental Research 60, 878-882
   Abstract »    PDF »
Interrelations of Oral Microorganisms, Immunoglobulins, and Dental Caries Following Radiotherapy.
L. R. Brown, S. Dreizen, T. E. Daly, J. B. Drane, S. Handler, L. J. Riggan, and D. A. Johnston (1978)
Journal of Dental Research 57, 882-893
   Abstract »    PDF »
A Plastic Intraoral Device for the Collection of Human Parotid Saliva.
M. E. Schaefer, M. Rhodes, S. Prince, S. M. Michalek, and J. R. McGhee (1977)
Journal of Dental Research 56, 728-733
   Abstract »    PDF »
Ingestion of Streptococcus mutans induces secretory immunoglobulin A and caries immunity.
S. Michalek, McGhee JR, J Mestecky, R. Arnold, and L Bozzo (1976)
Science 192, 1238-1240
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)