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Science 19 December 1975:
Vol. 190. no. 4220, pp. 1202 - 1204
DOI: 10.1126/science.1198105
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Articles

Science, Vol 190, Issue 4220, 1202-1204
Copyright © 1975 by American Association for the Advancement of Science

articles

Retention of nonhelical procollagen containing cis-hydroxyproline in rough endoplasmic reticulum

J Uitto, H Hoffman, and DJ Prockop

Fibroblasts freshly isolated from embryonic tendons were incubated with a proline analog, cis-4-hydroxy-L-proline, which is incorporated into protein and which leads to the intracellular accumulation of nonhelical procollagen. Evidence is presented here that the nonhelical procollagen containing the analog is retained within the rough endoplasmic reticulum and does not pass to the smooth endoplasmic reticulum or Golgi vacuoles at a normal rate.


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