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Science 19 December 1975:
Vol. 190. no. 4220, pp. 1200 - 1202
DOI: 10.1126/science.173020
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Articles

Science, Vol 190, Issue 4220, 1200-1202
Copyright © 1975 by American Association for the Advancement of Science

articles

Tumorigenicity of mouse-human diploid hybrids in nude mice

CM Croce, C Aden, and H Koprowski

Somatic cell hybrids between normal mouse cells and simian virus 40 (SV40)-transformed human cells, which contained a diploid complement of mouse chromosomes and the human chromosome 7 carrying the genome of SV40, were tumorigenic in nude mice. One single copy of human chromosome 7 per hybrid cell appeared to be sufficient for the tumorigenicity of the hybrids.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Location of gene for beta subunit of human T-cell receptor at band 7q35, a region prone to rearrangements in T cells.
M Isobe, J Erikson, B. Emanuel, P. Nowell, and C. Croce (1985)
Science 228, 580-582
   Abstract »    PDF »
Human cell hybrids: analysis of transformation and tumorigenicity.
E. Stanbridge, C. Der, C. Doersen, R. Nishimi, D. Peehl, B. Weissman, and J. Wilkinson (1982)
Science 215, 252-259
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)