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Science 12 December 1975:
Vol. 190. no. 4219, pp. 1108 - 1110
DOI: 10.1126/science.1237933
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Articles

Science, Vol 190, Issue 4219, 1108-1110
Copyright © 1975 by American Association for the Advancement of Science

articles

Infectious etiology of neuritic (senile) plaques in mice

HM Wisniewski, ME Bruce, and H Fraser

Brains of inbred female VM mice infected with scrapie agent were studied with the use of the Bodian silver impregnation method and by electron microscopy. In brains affected with scrapie, after an incubation period of between 587 and 655 days, numerous primitive, classical, and amyloid plaques were found. No plaques of any type were seen in the control mice.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cloning of a gene whose expression is increased in scrapie and in senile plaques in human brain.
S Wietgrefe, M Zupancic, A Haase, B Chesebro, R Race, W Frey 2nd, T Rustan, and R. Friedman (1985)
Science 230, 1177-1179
   Abstract »    PDF »
Infection-specific particle from the unconventional slow virus diseases.
P. Merz, R. Rohwer, R Kascsak, H. Wisniewski, R. Somerville, C. Gibbs Jr, and D. Gajdusek (1984)
Science 225, 437-440
   Abstract »    PDF »


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