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Science 12 December 1975:
Vol. 190. no. 4219, pp. 1103 - 1105
DOI: 10.1126/science.810892
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Articles

Science, Vol 190, Issue 4219, 1103-1105
Copyright © 1975 by American Association for the Advancement of Science

articles

Neisseria gonorrhoeae and neisseria meningitidis: extracellular enzyme cleaves human immunoglobulin A

AG Plaut, JV Gilbert, MS Artenstein, and JD Capra

The gonococcus and meningococcus, which infect human mucosal surfaces, elaborate a highly specific proteolytic enzyme which cleaves the immunoglobulin A1 subclass of the principal mucosal antibody, immunoglobulin A (IgA). The susceptible Pro-Thr bond lies in a unique region of the IgA heavy chain; the IgA2 subclass, lacking this peptide bond, is enzyme resistant.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Microbial IgA Protease Removes IgA Immune Complexes from Mouse Glomeruli In Vivo: Potential Therapy for IgA Nephropathy.
M. E. Lamm, S. N. Emancipator, J. K. Robinson, M. Yamashita, H. Fujioka, J. Qiu, and A. G. Plaut (2008)
Am. J. Pathol. 172, 31-36
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Characterization of igaB, a Second Immunoglobulin A1 Protease Gene in Nontypeable Haemophilus influenzae..
M. M. Fernaays, A. J. Lesse, X. Cai, and T. F. Murphy (2006)
Infect. Immun. 74, 5860-5870
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Type V Protein Secretion Pathway: the Autotransporter Story.
I. R. Henderson, F. Navarro-Garcia, M. Desvaux, R. C. Fernandez, and D. Ala'Aldeen (2004)
Microbiol. Mol. Biol. Rev. 68, 692-744
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EndoS and SpeB from Streptococcus pyogenes Inhibit Immunoglobulin-Mediated Opsonophagocytosis.
M. Collin, M. D. Svensson, A. G. Sjoholm, J. C. Jensenius, U. Sjobring, and A. Olsen (2002)
Infect. Immun. 70, 6646-6651
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Adaptive Evolution of the IgA Hinge Region in Primates.
K. Sumiyama, N. Saitou, and S. Ueda (2002)
Mol. Biol. Evol. 19, 1093-1099
   Abstract »    Full Text »    PDF »
Neisserial Immunoglobulin A1 Protease Induces Specific T-Cell Responses in Humans.
A. Tsirpouchtsidis, R. Hurwitz, V. Brinkmann, T. F. Meyer, and G. Haas (2002)
Infect. Immun. 70, 335-344
   Abstract »    Full Text »    PDF »
Activity of Human IgG and IgA Subclasses in Immune Defense Against Neisseria meningitidis Serogroup B.
G. Vidarsson, W.-L. van der Pol, J. M. H. van den Elsen, H. Vile, M. Jansen, J. Duijs, H. C. Morton, E. Boel, M. R. Daha, B. Corthesy, et al. (2001)
J. Immunol. 166, 6250-6256
   Abstract »    Full Text »    PDF »
Effects of the Immunoglobulin A1 Protease on Neisseria gonorrhoeae Trafficking across Polarized T84 Epithelial Monolayers.
S. Hopper, B. Vasquez, A. Merz, S. Clary, J. S. Wilbur, and M. So (2000)
Infect. Immun. 68, 906-911
   Abstract »    Full Text »    PDF »
Immunoglobulin A1 Protease, an Exoenzyme of Pathogenic Neisseriae, Is a Potent Inducer of Proinflammatory Cytokines.
D. R. Lorenzen, F. Dux, U. Wolk, A. Tsirpouchtsidis, G. Haas, and T. F. Meyer (1999)
J. Exp. Med. 190, 1049-1058
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Limited Local and Systemic Antibody Responses to Neisseria gonorrhoeae during Uncomplicated Genital Infections.
S. R. Hedges, M. S. Mayo, J. Mestecky, E. W. Hook III, and M. W. Russell (1999)
Infect. Immun. 67, 3937-3946
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A Neisseria gonorrhoeae Immunoglobulin A1 Protease Mutant Is Infectious in the Human Challenge Model of Urethral Infection.
D. B. Johannsen, D. M. Johnston, H. O. Koymen, M. S. Cohen, and J. G. Cannon (1999)
Infect. Immun. 67, 3009-3013
   Abstract »    Full Text »    PDF »
Evaluation of Immunoglobulin A1 (IgA1) Protease and IgA1 Protease-Inhibitory Activity in Human Female Genital Infection with Neisseria gonorrhoeae.
S. R. Hedges, M. S. Mayo, L. Kallman, J. Mestecky, E. W. Hook III, and M. W. Russell (1998)
Infect. Immun. 66, 5826-5832
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Comparisons of the Ability of Human IgG3 Hinge Mutants, IgM, IgE, and IgA2, to Form Small Immune Complexes: A Role for Flexibility and Geometry.
K. H. Roux, L. Strelets, O. H. Brekke, I. Sandlie, and T. E. Michaelsen (1998)
J. Immunol. 161, 4083-4090
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Infection of Epithelial Cells by Pathogenic Neisseriae Reduces the Levels of Multiple Lysosomal Constituents.
P. Ayala, L. Lin, S. Hopper, M. Fukuda, and M. So (1998)
Infect. Immun. 66, 5001-5007
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Pathogenesis of Pelvic Inflammatory Disease: What Are the Questions?.
P. A. Rice and J. Schachter (1991)
JAMA 266, 2587-2593
   Abstract »    PDF »


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