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Science 5 December 1975:
Vol. 190. no. 4218, pp. 994 - 997
DOI: 10.1126/science.1237932
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Articles

Science, Vol 190, Issue 4218, 994-997
Copyright © 1975 by American Association for the Advancement of Science

articles

Stage-specific switches in histone synthesis during embryogenesis of the sea urchin

LH Cohen, KM Newrock, and A Zweidler

Histones H2A and H2B of the sea urchin embryo have been resolved by new methods into components that are synthesized at different stages of development. One form of H2A and one form of H2B are synthesized only during the period from fertilization to the blastula stage. Subsequently, two other types of H2A and H2B molecules are synthesized. In addition, a histonelike protein was detected which is synthesized only from fertilization until the 16-cell stage when the synthesis of still another H2A-like protein begins. None of the late-appearing forms are derived from histone polypeptide chains synthesized earlier in development. Since the early components do not disappear after their synthesis stops, these modulations of histone synthesis lead to an increase in histone multiplicity, concomitant with the beginning of cell diversification and a decrease in cell division rate.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Probing the Conformation of Nucleosome Linker DNA in Situ with Pyrimidine Dimer Formation.
J. R. Pehrson and J. R. Pehrson (1995)
J. Biol. Chem. 270, 22440-22444
   Abstract »    Full Text »    PDF »
Activation of dormant genes in specialized cells.
M. DiBerardino, N. Hoffner, and L. Etkin (1984)
Science 224, 946-952
   Abstract »    PDF »
Gene expression in eukaryotes.
D. Brown (1981)
Science 211, 667-674
   Abstract »    PDF »
Histone gene expression: progeny of isolated early blastomeres in culture make the same change as in the embryo.
R. Arceci and P. Gross (1980)
Science 209, 607-609
   Abstract »    PDF »
Chromosomal subunits in active genes have an altered conformation.
H Weintraub and M Groudine (1976)
Science 193, 848-856
   Abstract »    PDF »


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