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Science 5 December 1975:
Vol. 190. no. 4218, pp. 991 - 992
DOI: 10.1126/science.242076
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Articles

Science, Vol 190, Issue 4218, 991-992
Copyright © 1975 by American Association for the Advancement of Science

articles

Reproductive tract lesions in male mice exposed prenatally to diethylstilbestrol

JA McLachlan, RR Newbold, and B Bullock

Sixty percent of the male offspring from pregnant mice treated with diethylstilbestrol during gestation were sterile. The affected animals had gonadal changes which included intra-abdominal or fibrotic testes, or both. Additionally, nodular masses in the ampullary region of the reproductive tract were observed in 6 of 24 animals; one of these appeared to be preneoplastic.


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