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Science 28 November 1975:
Vol. 190. no. 4217, pp. 910 - 912
DOI: 10.1126/science.1242543
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Articles

Science, Vol 190, Issue 4217, 910-912
Copyright © 1975 by American Association for the Advancement of Science

articles

Biogenesis of erythropoietin: evidence for pro-erythropoietin in a subcellular fraction of kidney

C Peschle and M Condorelli

The light mitochondrial fraction of hypoxic rodent kidneys, called the renal erythropoietic factor, contains erythropoietin in a pro, or active form. Erythropoietin is released from this inactive form when the renal erythropoietic factor is incubated with normal serum. The biogenesis of erythropoietin possibly involves a system in kidney reminiscent of the proinsulin-insulin system in pancreas.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)