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Science 28 November 1975:
Vol. 190. no. 4217, pp. 896 - 898
DOI: 10.1126/science.171770
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Articles
Science, Vol 190, Issue 4217, 896-898
Copyright © 1975 by American Association for the Advancement of Science
Cyclic AMP-dependent protein kinase: pivotal role in regulation of enzyme induction and growth
PA Insel,
HR Bourne,
P Coffino,
and
GM Tomkins
Dibutyryl cyclic adenosine 3',5'-monophosphate (cyclic AMP) produces phosphodiesterase induction, growth arrest, and cytolysis in S49 lymphoma cells. The striking parallelism between protein kinase activity that is dependent on cytosol cyclic AMP and cellular responses to dibutyryl cyclic AMP in wild-type cells and three classes of clones resistant to cyclic AMP indicates that protein kinase mediates cyclic AMP regulation of growth and enzyme induction in S49 cells.
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