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Science 28 November 1975:
Vol. 190. no. 4217, pp. 894 - 896
DOI: 10.1126/science.1188369
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Articles

Science, Vol 190, Issue 4217, 894-896
Copyright © 1975 by American Association for the Advancement of Science

articles

Prostaglandin F2alpha production by the brain during estrogen-induced secretion of luteinizing hormone

JS Roberts and JA McCracken

The arteriovenous difference in the concentration of prostaglandin F2alpha (PGF2alpha) across the brain of the anestrous sheep was measured before and during the induction of luteinizing hormone secretion with 17 beta-estradiol. The results indicate that (i) the brain in vivo is a significant source of PGF2alpha, (ii) the release of PGF2alpha from the brain occurs in pulses with a circhoral rhythm, and (iii) the process through which estrogen exerts its negative and positive feedback effects on luteinizing hormone secretion may involve amplitude modulation of PGF2alpha output from the brain.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Hydrogen peroxide induces spawning in mollusks, with activation of prostaglandin endoperoxide synthetase.
D. Morse, H Duncan, N Hooker, and A Morse (1977)
Science 196, 298-300
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