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Science 28 November 1975:
Vol. 190. no. 4217, pp. 889 - 890
DOI: 10.1126/science.242075
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Articles

Science, Vol 190, Issue 4217, 889-890
Copyright © 1975 by American Association for the Advancement of Science

articles

Substance p: localization in the central nervous system and in some primary sensory neurons

T Hokfelt, JO Kellerth, G Nilsson, and B Pernow

Antibodies to substance P with a high titer have been produced and used in immunohistochemical studies on the peripheral and central nervous system of the rat and the cat. Evidence was obtained for the localization of substance P in a certain population of primary sensory neurons, probably small nerve cells with unmyelinated processes. Substance P or a peptide similar to it was also observed in cell bodies in the medial habenula and in probable nerve terminals in many brain areas. The results give morphological support for a transmitter (or modulator) role of substance P in the nervous system.


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