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Science 21 November 1975:
Vol. 190. no. 4216, pp. 792 - 794
DOI: 10.1126/science.1105787
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Articles

Science, Vol 190, Issue 4216, 792-794
Copyright © 1975 by American Association for the Advancement of Science

articles

Mefloquine (WR 142,490) in the treatment of human malaria

CM Trenholme, RL Williams, RE Desjardins, H Frischer, PE Carson, KH Rieckmann, and CJ Canfield

Mefloquine hydrochloride, a new 4-quinolinemethanol, was administered as a single oral dose to 47 volunteers infected with malaria. Treatment resulted in rapid clearence of fever and parasitemia. No recrudescence of parasites was observed after treatment of chloroquine-sensitive infections of Plasmodium falciparum. More significantly, in nonimmune persons with chloroquine-resistant infections, 1 gram of mefloquine cured 10 of 12 patients and 1.5 grams cured all 8 patients who received this dose of the drug. The marked activity of a single dose of mefloquine against chloroquine-resistant strains of Plasmodium falciparum suggests that this agent may be more useful than currently available drugs are for the treatment of drug-resistant malaria.


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