Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 14 November 1975:
Vol. 190. no. 4215, pp. 673 - 675
DOI: 10.1126/science.1188362
Prev | Table of Contents | Next

Articles

Science, Vol 190, Issue 4215, 673-675
Copyright © 1975 by American Association for the Advancement of Science

articles

Alpha-lactalbumin production in human mammary carcinoma

HN Rose and CM McGrath

Alpha-Lactalbumin was isolated from mature human milk and utilized as an immunogen in rabbits. A radioimmunoassay was developed that was capable of detecting nanogram quantities of the antigen. Alpha-Lactalbumin synthesis was detected in human breast cancer cells (MCF-7) cultivated as a continuous cell line in vitro. Other human carcinoma epithelial cell lines (throat and cervix) failed to react in this assay. The ability to synthesize alpha-lactalbumin by breast carcinoma cells appeared to be independent of the addition of prolactin to the culture medium.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Perspectives in the Treatment of Breast Cancer: 1976.
R. C. YOUNG, M. LIPPMAN, V. T. DEVITA, J. BULL, and D. TORMEY (1977)
Ann Intern Med 86, 784-798
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)