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Science 7 November 1975:
Vol. 190. no. 4214, pp. 588 - 590
DOI: 10.1126/science.810889
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Articles

Science, Vol 190, Issue 4214, 588-590
Copyright © 1975 by American Association for the Advancement of Science

articles

Dyskinesias elicited by methamphetamine: susceptibility of former methadone-consuming monkeys

RD Eibergen and KR Carlson

Rhesus monkeys with a history of drinking methadone but currently drug-free and control monkeys with no drug history were injected with methamphetamine hydrochloride (2 to 5 milligrams per kilogram of body weight). In six of seven monkeys which had consumed methadone the lowest dose immediately elicited pronounced oral dyskinesias virtually identical to those of human tardive dyskinesia. The control monkeys did not exhibit oral dyskinesias even after prolonged treatment with the highest dose. The clincial implications may be related to the functioning of brain dopaminergic systems.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)