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Science 7 November 1975:
Vol. 190. no. 4214, pp. 578 - 580
DOI: 10.1126/science.1188357
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Articles

Science, Vol 190, Issue 4214, 578-580
Copyright © 1975 by American Association for the Advancement of Science

articles

Regulation of serum 1alpha,25-dihydroxyvitamin D3 by calcium and phosphate in the rat

MR Hughes, PF Brumbaugh, MR Hussler, JE Wergedal, and DJ Baylink

A new radioreceptor assay was used to quantify changes in serum concentration of 1alpha,25-dihydroxyvitamin D3 in rats with low calcium or low phosphate diets. Low availability of either ion elicits a fivefold increase in the circulating concentration of 1alpha,25-dihydroxyvitamin D3. The enhancement of 1alpha,25-dihydroxyvitamin D3 concentration in response to calcium deficiency is dependent on the presence of the parathyroid or thyroid glands (or both), suggesting that this effect is mediated by parathyroid hormone. In contrast, the response of phosphate deficiency is independent of these glands and may result from an action of low serum phosphate concentration or some factor associated with phosphate depletion on the renal synthesis of the 1alpha,25-dihydroxyvitamin D3 hormone.


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