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Science 7 November 1975:
Vol. 190. no. 4214, pp. 571 - 572
DOI: 10.1126/science.1103289
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Articles

Science, Vol 190, Issue 4214, 571-572
Copyright © 1975 by American Association for the Advancement of Science

articles

Transmission of Creutzfeldt-Jakob disease from man to the guinea pig

EE Manuelidis

Intracerebral and intraperitoneal inoculation of two guinea pigs with biopsy material from a patient with Creutzfeldt-Jakob disease produced a similar fatal encephalopathy characterized by status spongiosus 422 and 512 days after inoculation. Serial transmission of this disease from guinea pig to guinea pig was achieved in subsequent passages.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Viremia in experimental Creutzfeldt-Jakob disease.
E. Manuelidis, E. Gorgacs, and L Manuelidis (1978)
Science 200, 1069-1071
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Unconventional viruses and the origin and disappearance of kuru.
D. Gajdusek (1977)
Science 197, 943-960
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