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Science 24 October 1975:
Vol. 190. no. 4212, pp. 397 - 399
DOI: 10.1126/science.1179220
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Articles

Science, Vol 190, Issue 4212, 397-399
Copyright © 1975 by American Association for the Advancement of Science

articles

Myasthenia gravis: passive transfer from man to mouse

KV Toyka, DB Brachman, A Pestronk, and I Kao

Daily injections into mice of an ammonium sulfate-precipitated immunoglobulin fraction of serum from patients with myasthenia gravis were carried out for up to 14 days. The mice showed reduced amplitudes of miniature endplate potentials and reduced numbers of acetylcholine receptors at the neuromuscular junctions. Some mice showed typical decremental responses on repetitive nerve stimulation, with reversal by neostigmine. This represents the first evidence of a circulating factor in the serum of patients with myasthenia gravis which on passive transfer reproduces features of the disease in experimental animals.


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