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Science 10 October 1975:
Vol. 190. no. 4210, pp. 159 - 161
DOI: 10.1126/science.1166306
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Articles

Science, Vol 190, Issue 4210, 159-161
Copyright © 1975 by American Association for the Advancement of Science

articles

Genetic control of chloroform toxicity in mice

RN Hill, TL Clemens, DK Liu, ES Vesell, and WD Johnson

Mouse strain differences suggest intermediate or multifactorial gentic control of chloroform-induced renal toxicity and death. The chloroform dose lethal to 50 percent of animals was four times higher in C57BL/6J males than in DBA/2J males. Twice as much chloroform accumulated in the kidneys of the sensitive as the resistant strain. First generation offspring were midway between parental strains for both parameters.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Re-evaluation of the 2-Year Chloroform Drinking Water Carcinogenicity Bioassay in Osborne-Mendel Rats Supports Chronic Renal Tubule Injury as the Mode of Action Underlying the Renal Tumor Response.
G. C. Hard, G. A. Boorman, and D. C. Wolf (2000)
Toxicol. Sci. 53, 237-244
   Abstract »    Full Text »    PDF »
Mechanisms of Chemically Induced Renal Carcinogenesis in the Laboratory Rodent.
G. C. Hard (1998)
Toxicol Pathol 26, 104-112
   Abstract »    PDF »


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