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Science 10 October 1975:
Vol. 190. no. 4210, pp. 157 - 159
DOI: 10.1126/science.241121
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Articles

Science, Vol 190, Issue 4210, 157-159
Copyright © 1975 by American Association for the Advancement of Science

articles

Neurotransmitters increase cyclic nucleotides in postganglionic neurons: immunocytochemical demonstration

JW Kebabian, FE Blood, AL Steiner, and P Greengard

Dopamine increases adenosine 3',5'-monophosphate (cyclic AMP) but not guanosine 3',5'-monophosphate (cyclic GMP) in slices of bovine sympathetic ganglion; this increase is localized to the postganglionic neurons. Conversely, acetylcholine increases cyclic GMP but not cycle AMP in the ganglion; this increase also occurs within postganglionic neurons. Thus, different neurotransmitters can selectively alter cyclic nucleotide levels within the same neuronal population.


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