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Science 10 October 1975:
Vol. 190. no. 4210, pp. 155 - 156
DOI: 10.1126/science.1166305
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Articles

Science, Vol 190, Issue 4210, 155-156
Copyright © 1975 by American Association for the Advancement of Science

articles

Delivery of a quaternary pyridinium salt across the blood-brain barrier by its dihydropyridine derivative

N Bodor, E Shek, and T Higuchi

A dihydropyridine-pyridine type redox system was successfully applied for delivering a quaternary pyridinium salt, N-methylpyridinium-2-aldoxime chloride (2-PAM), through the blood-brain barrier. The dihydropyridine derivative of 2-PAM was quickly oxidized to 2-PAM after crossing the blood-brain barrier. As a result of this approach, the brain cholinesterase blocked by organophosphates could be reactivated. The new method should be useful in delivering numerous drugs which are otherwise inaccessible to the brain because of their polar ionic character.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cholinesterase Reactivation in Vivo with a Novel Bis-Oxime Optimized by Computer-Aided Design.
P. I. Hammond, C. Kern, F. Hong, T. M. Kollmeyer, Y.-P. Pang, and S. Brimijoin (2003)
J. Pharmacol. Exp. Ther. 307, 190-196
   Abstract »    Full Text »    PDF »
Site-specific, sustained release of drugs to the brain.
N Bodor, H. Farag, and M. Brewster 3rd (1981)
Science 214, 1370-1372
   Abstract »    PDF »


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