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Science 3 October 1975:
Vol. 190. no. 4209, pp. 63 - 65
DOI: 10.1126/science.170678
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Articles

Science, Vol 190, Issue 4209, 63-65
Copyright © 1975 by American Association for the Advancement of Science

articles

Antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance

JS Flier, CR Kahn, J Roth, and RS Bar

Six patients with a unique form of diabetes associated with extreme insulin resistance have markedly reduced insulin binding to specific receptors on their circulating monocytes. When normal insulin receptors were exposed to serum or immunoglobulin fractions from three of these patients in vitro the specific binding defect was reproduced.


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