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Science 3 October 1975:
Vol. 190. no. 4209, pp. 56 - 58
DOI: 10.1126/science.170676
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Articles

Science, Vol 190, Issue 4209, 56-58
Copyright © 1975 by American Association for the Advancement of Science

articles

Enhancement of mouse cytomegalovirus infection during host-versus-graft reaction

BC Wu, JN Dowling, JA Armstrong, and M Ho

C3H/He mice chronically infected with murine cytomegalovirus were given skin allografts from histoincompatible BALB/c donors. A significant increase in cytomegalovirus titers occurred within 3 days after placement of the graft in the spleens and kidneys of the allograft recipients as compared with control animals. No significant changes in virus titers were detected in the salivary gland, lung, liver, or blood of allograft recipients. These results indicate that the host-versus-graft reaction alone can enhance murine cytomegalovirus in a chronically infected host and may help explain the high incidence of cytomegalovirus infection seen after renal and other allograft transplantation in man.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Detection of human cytomegalovirus in peripheral blood lymphocytes in a natural infection.
R. Schrier, J. Nelson, and M. Oldstone (1985)
Science 230, 1048-1051
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Molecular Epidemiology of Cytomegalovirus Infections Associated with Bone Marrow Transplantation.
D. J. WINSTON, E.-S. HUANG, M. J. MILLER, C.-H. LIN, W. G. HO, R. P. GALE, and R. E. CHAMPLIN (1985)
Ann Intern Med 102, 16-20
   Abstract »    PDF »
Oropharyngeal Excretion of Epstein-Barr Virus by Patients with Lymphoproliferative Disorders and by Recipients of Renal Homografts.
R. S. CHANG, J. P. LEWIS, R. D. REYNOLDS, M. J. SULLIVAN, and J. NEUMAN (1978)
Ann Intern Med 88, 34-40
   Abstract »    PDF »
Prevention of Cytomegalovirus Disease Following Renal Transplantation.
J. B. HANSHAW (1977)
Arch Pediatr Adolesc Med 131, 841-842
   Abstract »    PDF »
Primary and Secondary Cytomegalovirus Infection: Clinical Manifestations After Renal Transplantation.
S. Suwansirikul, N. Rao, J. N. Dowling, and M. Ho (1977)
Arch Intern Med 137, 1026-1029
   Abstract »    PDF »


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