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Science 3 October 1975:
Vol. 190. no. 4209, pp. 20 - 29
DOI: 10.1126/science.1101378
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Articles

Science, Vol 190, Issue 4209, 20-29
Copyright © 1975 by American Association for the Advancement of Science

articles

Lymphocyte surface immunoglobulins

JJ Marchalonis

Immunoglobulins have been isolated from the surface of B (bone marrow-derived) and T (thymus-derived) lymphocytes. Two types of membrane immunoglobulin occur on B lymphocytes; one type resembles the 200,000-dalton subunit of IgM, the second possesses a heavy chain electrophoretically distinct from mu chain and does not correspond to any of the known classes of mouse immunoglobulins. It might correspond to human sigma chain. T lymphocytes possess only one type of surface immunoglobulin. This molecule has a mass of approximately 200,000 daltons and contains light chains and heavy chains similar to, but not identical to, mu chains. Evidence now exists that surface IgM-like immunoglobulins of B lymphocytes and T lymphocytes activated to certain antigens can bind specifically to antigen. These observations suggest that surface immunoglobulin functions as a receptor for antigen on B cells and at least on some T cells. The mechanisms by which combination of antigen with surface immunoglobulin initiate differentiation remain to be determined.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Visualization of a guinea pig T lymphocyte surface component cross-reactive with immunoglobulin.
J. Marchalonis, C Bucana, L Hoyer, G. Warr, and M. Hanna Jr (1978)
Science 199, 433-435
   Abstract »    PDF »
Lymphocyte Surface Immunoglobulins: Evolutionary Origins and Involvement in Activation.
J. J. Marchalonis, J. M. Decker, D. DeLuca, J. M. Moseley, P. Smith, and G. W. Warr (1977)
Cold Spring Harb Symp Quant Biol 41, 261-273
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)