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Science 19 September 1975:
Vol. 189. no. 4207, pp. 1009 - 1011
DOI: 10.1126/science.1220006
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Articles

Science, Vol 189, Issue 4207, 1009-1011
Copyright © 1975 by American Association for the Advancement of Science

articles

Diphenylhydantoin: action of a common anticonvulsant on bursting pacemaker cells in Aplysia

D Johnston and GF Avala

A commonly used anticonvulsant, diphenylhydantoin (Dilantin), decreases the bursting pacemaker activity in certain cells of Aplysia. Dilantin decreases this bursting activity whether it is endogenous to the cell or induced by a convulsant agent. The sodium-dependent negative resistance characteristic which is essential for bursting behavior is reduced in the presence of Dilantin.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)