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Science 5 September 1975:
Vol. 189. no. 4205, pp. 800 - 802
DOI: 10.1126/science.1172293
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Articles

Science, Vol 189, Issue 4205, 800-802
Copyright © 1975 by American Association for the Advancement of Science

articles

Epidermal growth factor: identification of a new hormone in human urine

RH Starkey, S Cohen, and DN Orth

Epidermal growth factor is a polypeptide hormone that was previously identified only in mice. It causes proliferation and keratinization of epidermal tissues. An immune affinity column extraction technique was used to purify partially a substance from human urine which was similar to the mouse hormone in both its biological activity and immunoreactivity.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Origins of Growth Factors: NGF and EGF.
S. Cohen (2008)
J. Biol. Chem. 283, 33793-33797
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Signals from the Past.
L. B. Ray, E. M. Adler, and N. R. Gough (2005)
Sci. STKE 2005, eg6
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Effect of Topically Administered Epidermal Growth Factor on Corneal Wound Strength.
H. M. Leibowitz, S. Morello Jr, M. Stern, and A. Kupferman (1990)
Arch Ophthalmol 108, 734-737
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The Effect of Desalivation Upon Pulpal Function and Dental Caries in Rats.
R.R. Steinman, J. Leonora, and R. J. Singh (1980)
Journal of Dental Research 59, 176-185
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Salivary gland hyperglycemic factor: an extrapancreatic source of glucagon-like material.
A. Lawrence, S Tan, S Hojvat, and L Kirsteins (1977)
Science 195, 70-72
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