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Science 29 August 1975:
Vol. 189. no. 4204, pp. 727 - 729
DOI: 10.1126/science.168641
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Articles

Science, Vol 189, Issue 4204, 727-729
Copyright © 1975 by American Association for the Advancement of Science

articles

Acetaldehyde oxidation by hepatic mitochondria: decrease after chronic ethanol consumption

Y Hasumura, R Teschke, and CS Lieber

Prolonged consumption of ethanol significantly reduces the capacity of rat liver mitochondria to oxidize acetaldehyde. This is associated with decreased mitochondrial respiration with acetaldehyde as substrate. The reduced ability of mitochondria to metabolize acetaldehyde may explain the high levels of acetaldehyde in the blood of alcoholics, which in turn could promote the perpetuation of liver injury.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)