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Science 8 August 1975:
Vol. 189. no. 4201, pp. 480 - 482
DOI: 10.1126/science.50621
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Articles

Science, Vol 189, Issue 4201, 480-482
Copyright © 1975 by American Association for the Advancement of Science

articles

Central projection of optic tract from translocated eyes in the leopard frog (Rana pipiens)

M Constantine-Paton and RR Caprianica

In Rana pipiens embryos, eye anlagen were moved to the evacuated ear position, where they continued to differentiate and sent their optic nerve fibers into the hindbrain. Upon entering the medulla, the optic fibers turned caudally, penetrated the spinal cord, and traversed the dorsolateral white matter to the caudal end. We found this pattern of growth in every animal; the optic fibers did not enter the tecta. These results suggest the existence within the neural tube of a three-dimensional gradient system to which embryonic optic fibers are responsive and which may guide the normal development of the visual pathway.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Eyes transplanted to tadpole tails send axons rostrally in two spinal-cord tracts.
M. Katz and R. Lasek (1978)
Science 199, 202-204
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Trophic regulation of nerve sprouting.
J Diamond, E Cooper, C Turner, and L Macintyre (1976)
Science 193, 371-377
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