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Science 8 August 1975:
Vol. 189. no. 4201, pp. 467 - 469
DOI: 10.1126/science.168639
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Articles

Science, Vol 189, Issue 4201, 467-469
Copyright © 1975 by American Association for the Advancement of Science

articles

Cyclic AMP and cyclic GMP: mediators of the mechanical effects on bone remodeling

GA Rodan, LA Bourret, A Harvey, and T Mensi

Compressive forces of physiological magnitude (60 grams per square centimeter) reduce the adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate content of the epiphyses of tibiae from 16-day-old chick embryos. An equivalent hydrostatic pressure applied directly to cells isolated from this tissue also affects cyclic nucleotide accumulation. The tissue response is uniform throughout the epiphysis, whereas the cell response varies according to the area of origin.


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